Drizzle ORM natively supports aws-sdk driver with drizzle-orm/aws-data-api package.

npm
yarn
pnpm
bun
npm i drizzle-orm @aws-sdk/client-rds-data @aws-sdk/credential-providers
npm i -D drizzle-kit
index.ts
import { drizzle } from 'drizzle-orm/aws-data-api/pg';
import { RDSDataClient } from '@aws-sdk/client-rds-data';
import { fromIni } from '@aws-sdk/credential-providers';

const rdsClient = new RDSDataClient({
    credentials: fromIni({ profile: process.env['PROFILE'] }),
    region: 'us-east-1',
});

const db = drizzle(rdsClient, {
  database: process.env['DATABASE']!,
  secretArn: process.env['SECRET_ARN']!,
  resourceArn: process.env['RESOURCE_ARN']!,
});

await db.select().from(...)...;